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Details on Person APC/C:Cdh1 polyubiquitinates SKP2

Class:Id	Reaction:9686969
_displayName	APC/C:Cdh1 polyubiquitinates SKP2
_doRelease	TRUE
_timestamp	2022-02-08 22:23:25
authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
catalystActivity	[CatalystActivity:9687072] ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9686975] Orlic-Milacic, Marija, 2020-05-05
edited	[InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
input	[Complex:9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
modified	[InstanceEdit:9687075] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687090] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687149] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687398] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18 [InstanceEdit:9764086] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	APC/C:Cdh1 polyubiquitinates SKP2
negativePrecedingEvent	[NegativePrecedingEvent:9764079] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764078] Futile Cycle: Degradation of multiubiquitinated Cdh1
output	[Complex:188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9686983] R-HSA-9686969.3
summation	[Summation:9687088] RB1-dependent polyubiquitination of SKP2 by the APC/C:Cdh1 c...
(hasEvent)	[Pathway:174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:188191] APC/C:Cdh1-mediated degradation of Skp2 [Homo sapiens]
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No pathways have been reviewed or authored by APC/C:Cdh1 polyubiquitinates SKP2 (9686969)