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Details on Person RIPK3 is cleaved by CASP8

Class:IdBlackBoxEvent:9686930
_displayNameRIPK3 is cleaved by CASP8
_doReleaseTRUE
_timestamp2020-09-10 14:54:38
authored[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
catalystActivity[CatalystActivity:139951] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9686929] Shamovsky, Veronica, 2020-05-05
edited[InstanceEdit:9698642] Shamovsky, Veronica, 2020-08-28
input[EntityWithAccessionedSequence:450328] RIPK3 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5621072] Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
modified[InstanceEdit:9696115] Shamovsky, Veronica, 2020-07-17
[InstanceEdit:9697382] Shamovsky, Veronica, 2020-08-14
[InstanceEdit:9697735] Shamovsky, Veronica, 2020-08-20
[InstanceEdit:9698854] Shamovsky, Veronica, 2020-08-30
[InstanceEdit:9699085] Shamovsky, Veronica, 2020-09-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRIPK3 is cleaved by CASP8
output[EntityWithAccessionedSequence:9686917] RIPK3(1-328) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9686937] RIPK3(329-518) [cytosol] [Homo sapiens]
precedingEvent
releaseDate2020-09-15
requiredInputComponent[Complex:2562550] active caspase-8 [cytosol] [Homo sapiens]
reviewed[InstanceEdit:9692900] D'Eustachio, Peter, 2020-06-26
[InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9686945] R-HSA-9686930.2
summation[Summation:9686908] Caspase-8 (CASP8) in human and rodent cells facilitates the ...
(hasEvent)[Pathway:5675482] Regulation of necroptotic cell death [Homo sapiens]
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No pathways have been reviewed or authored by RIPK3 is cleaved by CASP8 (9686930)