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Details on Person During apoptosis, activated caspase-3 (CASP3) and to a lesse...
| Class:Id | Summation:9686089 |
|---|---|
| _displayName | During apoptosis, activated caspase-3 (CASP3) and to a lesse... |
| _timestamp | 2021-04-22 04:31:41 |
| created | [InstanceEdit:9686081] Shamovsky, Veronica, 2020-04-28 |
| literatureReference | [LiteratureReference:9686128] Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages |
| modified | [InstanceEdit:9686268] Shamovsky, Veronica, 2020-04-29 [InstanceEdit:9710034] Shamovsky, Veronica, 2020-12-25 [InstanceEdit:9711033] Shamovsky, Veronica, 2021-01-07 [InstanceEdit:9716212] Shamovsky, Veronica, 2021-02-19 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 |
| text | During apoptosis, activated caspase-3 (CASP3) and to a lesser degree CASP7 inactivate gasdermin D (GSDMD) by cleaving GSDMD at position D87 generating p20 (GSDMD(1-87)) and p43 (GSDMD(88-484)) fragments (Taabazuing CY et al. 2017). This cleavage site is evolutionarily conserved and lies within the N-terminal fragment (p30, GSDMD(1-275)) that forms membrane pores. Proteolysis at this site renders GSDMD incapable of activating pyroptosis (Taabazuing CY et al. 2017). This pathway does not seem to play a key role during animal development as wild-type and Gsdmd-deficient mice both develop normally. |
| (summation) | [BlackBoxEvent:9686088] CASP3 cleaves GSDMD [Homo sapiens] |
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No pathways have been reviewed or authored by During apoptosis, activated caspase-3 (CASP3) and to a lesse... (9686089)
