Query author contributions in Reactome
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Details on Person The antitussive drug dextromethorphan can elicit antidepress...
| Class:Id | Summation:9685770 |
|---|---|
| _displayName | The antitussive drug dextromethorphan can elicit antidepress... |
| _timestamp | 2020-04-27 15:25:58 |
| created | [InstanceEdit:9685756] Jassal, Bijay, 2020-04-27 |
| literatureReference | [LiteratureReference:9685828] Current Perspectives for the use of Gonane Progesteronergic Drugs in the Treatment of Central Hypoventilation Syndromes [LiteratureReference:9685815] Sigma receptors: potential targets for a new class of antidepressant drug |
| text | The antitussive drug dextromethorphan can elicit antidepressant-like actions at least in part through binding and stimulating the sigma non-opioid intracellular receptor 1 (SIGMAR1) (Lauterbach 2012, Fishback et al. 2010). Its endogenous ligand may be progesterone (Ganapathy et al. 1999). Small anecdotal studies suggest that ligands that target SIGMAR1 may be useful in treating central hypoventilation syndromes (Loiseau et al. 2018), suggesting a possible role for such drugs in treatment of COVID-19 symptoms. |
| (summation) | [Reaction:9679816] SIGMAR1 binds dextromethorphan [Homo sapiens] |
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No pathways have been reviewed or authored by The antitussive drug dextromethorphan can elicit antidepress... (9685770)
