Query author contributions in Reactome
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Details on Person TNF-alpha signaling leads to the assembly of a large recepto...
| Class:Id | Summation:9685671 |
|---|---|
| _displayName | TNF-alpha signaling leads to the assembly of a large recepto... |
| _timestamp | 2020-04-24 15:31:01 |
| created | [InstanceEdit:9685670] Jassal, Bijay, 2020-04-24 |
| text | TNF-alpha signaling leads to the assembly of a large receptor-bound signaling complex, which includes multiple adaptors (TRADD, TRAF2, and RIPK1), and E3 ubiquitin ligases (cIAP1/2, LUBAC complex). RIPK1 thus plays a critical role in mediating both normal and pathological responses downstream of TNFR1 and RIPK1 inhibitors, including ponatrinib, have progressed successfully passed human phase I clinical studies (Degterev et al. 2020, Najjar et al. 2015). |
| (summation) | [Reaction:9679839] RIPK1 binds ponatinib [Homo sapiens] |
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No pathways have been reviewed or authored by TNF-alpha signaling leads to the assembly of a large recepto... (9685671)
