Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Integrins are the receptors that mediate cell adhesion to th...
| Class:Id | Summation:9685458 |
|---|---|
| _displayName | Integrins are the receptors that mediate cell adhesion to th... |
| _timestamp | 2020-04-24 15:31:04 |
| created | [InstanceEdit:9685462] Jassal, Bijay, 2020-04-23 |
| literatureReference | [LiteratureReference:9679785] Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody |
| modified | [InstanceEdit:9685670] Jassal, Bijay, 2020-04-24 |
| text | Integrins are the receptors that mediate cell adhesion to the extracellular matrix (ECM). They are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha-4 (ITGA4) is a receptor for fibronectin. ITGA4 functions as a heterodimer of an alpha subunit and the beta subunit of either the beta-1 chain or the beta-7 chain (ITGA4:ITGB1 shown here). Natalizumab (Tysabri) is a humanised monoclonal antibody against the cell adhesion molecule α4-integrin. It is a medication used to treat multiple sclerosis and Crohn's disease (No authors 2004). It binds to the α4-subunit of α4b1 and α4b7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptors. This is thought to reduce the ability of inflammatory immune cells to attach to and pass through the cell layers lining the intestines and blood–brain barrier (Rice et al. 2005). |
| (summation) | [Reaction:9679740] ITGA4:ITGB1 binds natalizumab [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Integrins are the receptors that mediate cell adhesion to th... (9685458)
