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Details on Person NLRP3:SUGT1:HSP90 binds MAVS

Class:IdReaction:9685270
_displayNameNLRP3:SUGT1:HSP90 binds MAVS
_doReleaseFALSE
_timestamp2021-07-23 21:25:03
compartment[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:9685275] Shamovsky, Veronica, 2020-04-23
input[Complex:874086] NLRP3:SUGT1:HSP90 [cytosol] [Homo sapiens]
[Complex:9709860] MAVS:TOMM70 [mitochondrial outer membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9708085] The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
[LiteratureReference:9708063] The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
modified[InstanceEdit:9686281] Shamovsky, Veronica, 2020-04-29
[InstanceEdit:9708886] Shamovsky, Veronica, 2020-12-03
[InstanceEdit:9712304] Shamovsky, Veronica, 2021-01-18
[InstanceEdit:9712467] Shamovsky, Veronica, 2021-01-21
[InstanceEdit:9736864] Shamovsky, Veronica, 2021-07-15
[InstanceEdit:9748659] Shamovsky, Veronica, 2021-07-23
nameNLRP3:SUGT1:HSP90 binds MAVS
output[Complex:9685256] NLRP3:MAVS:TOMM70 [mitochondrial outer membrane] [Homo sapiens]
[Complex:874112] SUGT1:HSP90 [cytosol] [Homo sapiens]
regulatedBy[NegativeRegulation:9712454] Negative regulation by 'NLRP3:NR0B2 [mitochondrial outer membrane]'
[NegativeRegulation:9748657] Negative regulation by 'SCF(FBXL2) complex:Ub-K689-NLRP3 [cytosol]'
regulationReference[RegulationReference:9712453] Negative regulation by 'NLRP3:NR0B2 [mitochondrial outer membrane]' Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9685284] R-HSA-9685270.1
summation[Summation:9708885] The mitochondrial antiviral-signaling protein (MAVS, IPS-1) ...
(hasEvent)[Pathway:9686280] NLRP3 inflammasome activation upon viral infection [Homo sapiens]
(precedingEvent)[Polymerisation:9686277] NLRP3 oligomerizes [Homo sapiens]
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No pathways have been reviewed or authored by NLRP3:SUGT1:HSP90 binds MAVS (9685270)