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Details on Person TRAF3 polyubiquitinates PYCARD

Class:IdBlackBoxEvent:9685243
_displayNameTRAF3 polyubiquitinates PYCARD
_doReleaseFALSE
_timestamp2022-05-31 18:42:25
catalystActivity[CatalystActivity:9685257] ubiquitin-protein transferase activity of NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane]
catalystActivityReference[CatalystActivityReference:9685261] ubiquitin-protein transferase activity of NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
compartment[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:9685275] Shamovsky, Veronica, 2020-04-23
input[Complex:9685251] NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] [Homo sapiens]
[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9685266] MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
modified[InstanceEdit:9686281] Shamovsky, Veronica, 2020-04-29
[InstanceEdit:9712304] Shamovsky, Veronica, 2021-01-18
[InstanceEdit:9736864] Shamovsky, Veronica, 2021-07-15
[InstanceEdit:9792814] Shamovsky, Veronica, 2022-05-31
nameTRAF3 polyubiquitinates PYCARD
output[Complex:9685247] NLRP3 oligomer:MAVS:TRAF3:K63polyUb-PYCARD [mitochondrial outer membrane] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9685279] Positive regulation by 'SARS CoV 3a:NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane]'
regulationReference[RegulationReference:9686282] Positive regulation by 'SARS CoV 3a:NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane]' Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9685294] R-HSA-9685243.1
summation[Summation:9712387] Coimmunoprecipitation experiments revealed that apoptosis-as...
(hasEvent)[Pathway:9686280] NLRP3 inflammasome activation upon viral infection [Homo sapiens]
(precedingEvent)[Polymerisation:9712318] PYCARD oligomerizes [Homo sapiens]
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No pathways have been reviewed or authored by TRAF3 polyubiquitinates PYCARD (9685243)