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Details on Person Severe acute respiratory syndrome coronavirus type 1(SARS-Co...
| Class:Id | Summation:9685223 |
|---|---|
| _displayName | Severe acute respiratory syndrome coronavirus type 1(SARS-Co... |
| _timestamp | 2021-01-27 01:40:35 |
| created | [InstanceEdit:9685206] Shamovsky, Veronica, 2020-04-23 |
| literatureReference | [LiteratureReference:9685225] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6 [LiteratureReference:9685222] Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme [LiteratureReference:9685215] The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme [LiteratureReference:9710698] The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity [LiteratureReference:9710695] The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds |
| modified | [InstanceEdit:9687134] Shamovsky, Veronica, 2020-05-06 [InstanceEdit:9705150] Shamovsky, Veronica, 2020-10-21 [InstanceEdit:9710697] Shamovsky, Veronica, 2021-01-05 [InstanceEdit:9713615] Shamovsky, Veronica, 2021-01-27 |
| text | Severe acute respiratory syndrome coronavirus type 1(SARS-CoV-1) 1a-encoded papain-like protease (PLPro or nsp3) is primarily involved in SARS-CoV-1 replication. In addition, viral nsp3 is thought to remove ubiquitin (Ub) and ISG15 proteins from host cell proteins by recognizing a consensus motif LXGG (Lindner HA et al. 2005; Barretto N et al. 2005; Ratia K et al. 2006). As a de-ubiquitinating/de-ISGylating enzyme, viral nsp3 antagonizes host type I interferon (IFN) responses by blocking signal transducers and mediators (Lindner HA et al. 2005; Barretto N et al. 2005; Ratia K et al. 2006; reviewed in Báez-Santos YM et al. 2014). Dual luciferase reporters, western blotting and real-time PCR assays showed suppressed activation of transcription factors IRF-3, NF-κB and AP-1 in nsp3-expressing human promonocyte cells treated with imiquimod (IMQ), a TLR7 ligand (Li SW et al. 2016). Western blot analysis with anti-Lys48 and anti-Lys63 ubiquitin antibodies showed that PLPro (nsp3) removed Lys63-linked ubiquitin chains of TRAF3 and TRAF6, but not Lys48-linked ubiquitin chains in untreated and treated cells (Li SW et al. 2016). Thus, SARS-CoV-1 nsp3 is thought to inhibit TLR7-mediated cytokine production through removing Lys63-linked polyubiquitin chains of TRAF3/TRAF6. |
| (summation) | [BlackBoxEvent:9685219] SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) [Homo sapiens] |
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