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Details on Person SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)

Class:Id	BlackBoxEvent:9685219
_displayName	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)
_doRelease	TRUE
_timestamp	2022-08-18 02:17:59
authored	[InstanceEdit:9692648] Shamovsky, Veronica, 2020-06-25
catalystActivity	[CatalystActivity:9685211] K63-linked deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane]
catalystActivityReference	[CatalystActivityReference:9685212] Lys63-specific deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9685206] Shamovsky, Veronica, 2020-04-23
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9796665] Shamovsky, Veronica, 2022-08-11
goBiologicalProcess	[GO_BiologicalProcess:2587979] symbiont-mediated perturbation of host ubiquitin-like protein modification
input	[Complex:975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9685225] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
modified	[InstanceEdit:9696755] Shamovsky, Veronica, 2020-07-29 [InstanceEdit:9711066] Shamovsky, Veronica, 2021-01-11 [InstanceEdit:9713614] Shamovsky, Veronica, 2021-01-27 [InstanceEdit:9796177] Shamovsky, Veronica, 2022-08-05 [InstanceEdit:9796527] Shamovsky, Veronica, 2022-08-10 [InstanceEdit:9796657] Shamovsky, Veronica, 2022-08-11 [InstanceEdit:9815491] Shamovsky, Veronica, 2022-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)
output	[Complex:975137] p-IRAK2:oligo-TRAF6 [endosome membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2022-09-14
reviewed	[InstanceEdit:9713569] D'Eustachio, Peter, 2021-01-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9685229] R-HSA-9685219.2
summation	[Summation:9685223] Severe acute respiratory syndrome coronavirus type 1(SARS-Co...
(hasEvent)	[Pathway:9692916] SARS-CoV-1 activates/modulates innate immune responses [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (9685219)