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Details on Person On viral infection poly(rC) binding protein 2 (PCBP2) binds ...
| Class:Id | Summation:9685183 |
|---|---|
| _displayName | On viral infection poly(rC) binding protein 2 (PCBP2) binds ... |
| _timestamp | 2022-08-11 01:28:59 |
| created | [InstanceEdit:9685194] Shamovsky, Veronica, 2020-04-23 |
| literatureReference | [LiteratureReference:9685176] SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome [LiteratureReference:983448] PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 |
| modified | [InstanceEdit:9693606] Shamovsky, Veronica, 2020-07-03 [InstanceEdit:9710707] Shamovsky, Veronica, 2021-01-05 [InstanceEdit:9713611] Shamovsky, Veronica, 2021-01-27 [InstanceEdit:9796650] Shamovsky, Veronica, 2022-08-11 |
| text | On viral infection poly(rC) binding protein 2 (PCBP2) binds mitochondrial antiviral signaling protein (MAVS or IPS-1) and recruits the HECT domain-containing E3 ligase AIP4 (or ITCH) (You F et al. 2009). ITCH catalyses K48-linked polyubiquitination to trigger degradation of MAVS via the proteasomal pathway. Severe acute respiratory syndrome coronavirus-1 (SARS-CoV-1) 9b (ORF9b) suppresses the MAVS-mediated signaling pathway by facilitating the recruitment of PCBP2 and ITCH to MAVS during viral infection (Shi CS et al. 2014). |
| (summation) | [BlackBoxEvent:9685195] SARS-CoV-1 9b recruits ITCH to MAVS [Homo sapiens] |
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No pathways have been reviewed or authored by On viral infection poly(rC) binding protein 2 (PCBP2) binds ... (9685183)
