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Details on Person IFIT1:IFIT3 binds viral m7G(5')pppN-mRNA

Class:Id	Reaction:9684493
_displayName	IFIT1:IFIT3 binds viral m7G(5')pppN-mRNA
_doRelease	TRUE
_timestamp	2026-05-19 13:08:18
authored	[InstanceEdit:9690051] Shamovsky, Veronica, 2020-05-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9684507] Shamovsky, Veronica, 2020-04-21
input	[Complex:9684506] IFIT1:IFIT3 [cytosol] [Homo sapiens] [CandidateSet:9684494] viral m7G(5')pppN-mRNA [cytosol] [Human SARS coronavirus]
internalReviewed	[InstanceEdit:9691728] Orlic-Milacic, Marija, 2020-06-18
isChimeric	FALSE
literatureReference	[LiteratureReference:9684553] Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability [LiteratureReference:9684537] IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA [LiteratureReference:9684534] Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells
modified	[InstanceEdit:9690557] Shamovsky, Veronica, 2020-06-03 [InstanceEdit:9690685] Shamovsky, Veronica, 2020-06-04 [InstanceEdit:9690755] Shamovsky, Veronica, 2020-06-05 [InstanceEdit:9691376] Shamovsky, Veronica, 2020-06-12 [InstanceEdit:9691468] Shamovsky, Veronica, 2020-06-16 [InstanceEdit:9691522] Shamovsky, Veronica, 2020-06-17 [InstanceEdit:9692472] Shamovsky, Veronica, 2020-06-24 [InstanceEdit:9706584] Shamovsky, Veronica, 2020-11-07 [InstanceEdit:9707141] Shamovsky, Veronica, 2020-11-11 [InstanceEdit:9710923] Shamovsky, Veronica, 2021-01-05 [InstanceEdit:9713606] Shamovsky, Veronica, 2021-01-27 [InstanceEdit:9796135] Shamovsky, Veronica, 2022-08-05 [InstanceEdit:9796655] Shamovsky, Veronica, 2022-08-11 [InstanceEdit:9978370] Shamovsky, Veronica, 2025-12-31 [InstanceEdit:9981401] Shamovsky, Veronica, 2026-02-08 [InstanceEdit:9983638] Shamovsky, Veronica, 2026-02-25 [InstanceEdit:9989199] Shamovsky, Veronica, 2026-05-19
name	IFIT1:IFIT3 binds viral m7G(5')pppN-mRNA
output	[Complex:9684453] IFIT1:IFIT3:IFIT1 ligand [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9684498] IFIT1 binds IFIT3 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:9691375] Negative regulation by 'RTC [double membrane vesicle viral factory outer membrane]' [NegativeRegulation:9691374] Negative regulation by 'WNV replication complex [endoplasmic reticulum membrane]'
regulationReference	[RegulationReference:9691370] Negative regulation by 'WNV RTC [endoplasmic reticulum membrane]' IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA [RegulationReference:9710710] Negative regulation by 'RTC [double membrane vesicle viral factory outer membrane]' Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:8983656] West Nile virus [Species:3244621] Dengue virus type 2
reviewed	[InstanceEdit:9989198] Hyde, Jennifer L, 2026-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9684584] R-HSA-9684493.1
summation	[Summation:9684530] Interferon-induced protein with tetratricopeptide repeats 1 ...
(hasEvent)	[Pathway:9684482] IFIT antiviral response [Homo sapiens] [Pathway:9692916] SARS-CoV-1 activates/modulates innate immune responses [Homo sapiens]
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No pathways have been reviewed or authored by IFIT1:IFIT3 binds viral m7G(5')pppN-mRNA (9684493)