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Details on Person 3CLp cleaves pp1ab

Class:Id	Reaction:9684340
_displayName	3CLp cleaves pp1ab
_doRelease	TRUE
_timestamp	2020-08-04 17:53:35
authored	[InstanceEdit:9683039] Stephan, Ralf, 2020-04-14
catalystActivity	[CatalystActivity:9684361] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9684359] Stephan, Ralf, 2020-04-21
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
input	[EntityWithAccessionedSequence:9684355] pp1ab [cytosol] [Human SARS coronavirus] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9684297] Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
modified	[InstanceEdit:9684393] Stephan, Ralf, 2020-04-21 [InstanceEdit:9684871] Stephan, Ralf, 2020-04-22 [InstanceEdit:9686289] Jassal, Bijay, 2020-04-29 [InstanceEdit:9686300] Stephan, Ralf, 2020-04-30 [InstanceEdit:9686631] Stephan, Ralf, 2020-05-04 [InstanceEdit:9686647] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689462] D'Eustachio, Peter, 2020-05-19 [InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690133] D'Eustachio, Peter, 2020-05-26 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9696769] Orlic-Milacic, Marija, 2020-07-29 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp cleaves pp1ab
output	[EntityWithAccessionedSequence:9684861] pp1ab-nsp1-4 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682196] pp1ab-nsp5 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682244] pp1ab-nsp7 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682232] pp1ab-nsp9 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9678280] pp1ab-nsp12 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9678281] pp1ab-nsp13 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9678285] pp1ab-nsp14 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9678288] pp1ab-nsp15 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9678289] pp1ab-nsp16 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682242] pp1ab-nsp8 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682216] pp1ab-nsp10 [cytosol] [Human SARS coronavirus] [EntityWithAccessionedSequence:9682233] pp1ab-nsp6 [endoplasmic reticulum membrane] [Human SARS coronavirus]
precedingEvent	[Reaction:9684323] 3CLp forms a homodimer [Homo sapiens] [Reaction:9684351] pp1a cleaves itself [Homo sapiens] [BlackBoxEvent:9684277] mRNA1 is translated to pp1ab [Homo sapiens]
regulatedBy	[NegativeRegulation:9686287] Negative regulation by '3CLp dimer:α-Ketoamides [cytosol]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9684379] R-HSA-9684340.3
summation	[Summation:9686301] Main protease cleaves all cleavage sites of pp1a and ppa1b s... [Summation:9684353] Main protease cleaves all cleavage sites of pp1a and ppa1b s...
(hasEvent)	[Pathway:9684325] Maturation of replicase proteins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9684282] nsp9 forms a homodimer [Homo sapiens] [Reaction:9684336] nsp1-4 cleaves itself [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776841] Update Tracker - [Reaction:9684340] 3CLp cleaves pp1ab - v74:[add_removeOutput]
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No pathways have been reviewed or authored by 3CLp cleaves pp1ab (9684340)