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Details on Person ERCC3-facilitated RNA Pol II backtracking in TC-NER

Class:Id	Reaction:9684118
_displayName	ERCC3-facilitated RNA Pol II backtracking in TC-NER
_doRelease	TRUE
_timestamp	2020-05-21 15:49:17
authored	[InstanceEdit:6782121] Orlic-Milacic, Marija, 2015-06-04
catalystActivity	[CatalystActivity:9684122] 3'-5' DNA helicase activity of TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9684116] Orlic-Milacic, Marija, 2020-04-20
edited	[InstanceEdit:9689740] Orlic-Milacic, Marija, 2020-05-21
input	[Complex:9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:5689311] Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair [LiteratureReference:5689302] Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
modified	[InstanceEdit:9689740] Orlic-Milacic, Marija, 2020-05-21 [InstanceEdit:9689741] Orlic-Milacic, Marija, 2020-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERCC3-facilitated RNA Pol II backtracking in TC-NER
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm] [Complex:6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER [Homo sapiens] [Reaction:6782069] UVSSA:USP7 deubiquitinates ERCC6 [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03 [InstanceEdit:9684094] D'Eustachio, Peter, 2020-04-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9684125] R-HSA-9684118.2
summation	[Summation:9684115] The DNA helicase XPB (ERCC3), which is part of the TFIIH com...
(hasEvent)	[Pathway:6782135] Dual incision in TC-NER [Homo sapiens]
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No pathways have been reviewed or authored by ERCC3-facilitated RNA Pol II backtracking in TC-NER (9684118)