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Details on Person nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)

Class:Id	BlackBoxEvent:9684018
_displayName	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
_doRelease	TRUE
_timestamp	2021-01-23 15:28:37
authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9713308] mRNA 5'-cap (guanine-N7-)-methyltransferase activity of SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9684019] Orlic-Milacic, Marija, 2020-04-20
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
input	[SimpleEntity:29438] GTP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9639461] S-adenosyl-L-methionine [cytosol] [Complex:9713316] SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9684025] Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
modified	[InstanceEdit:9684029] Orlic-Milacic, Marija, 2020-04-20 [InstanceEdit:9685146] Orlic-Milacic, Marija, 2020-04-22 [InstanceEdit:9685396] Orlic-Milacic, Marija, 2020-04-23 [InstanceEdit:9686425] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686435] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686647] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690155] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9713325] Orlic-Milacic, Marija, 2021-01-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
output	[SimpleEntity:111294] PPi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:9639443] S-adenosyl-L-homocysteine [cytosol] [Complex:9713306] m7GpppA-capped SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus]
precedingEvent	[BlackBoxEvent:9682465] RTC completes synthesis of the minus strand genomic RNA complement [Homo sapiens] [Reaction:9682603] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA [Homo sapiens]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9684021] R-HSA-9684018.4
summation	[Summation:9685395] The genomic and subgenomic mRNAs of SARS-CoV-1 coronavirus, ...
(hasEvent)	[Pathway:9682706] Replication of the SARS-CoV-1 genome [Homo sapiens]
(precedingEvent)	[Reaction:9684030] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776287] Update Tracker - [BlackBoxEvent:9684018] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - v76:[add_removeCatalystActivity, add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (9684018)