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Details on Person glycosylated-ACE2 [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9683480
_displayName	glycosylated-ACE2 [plasma membrane]
_timestamp	2020-04-16 14:51:40
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9683486] Jassal, Bijay, 2020-04-16
endCoordinate	805
hasModifiedResidue	[ModifiedResidue:9683475] N4-glycosyl-L-asparagine at 53 [ModifiedResidue:9683483] N4-glycosyl-L-asparagine at 90 [ModifiedResidue:9683464] N4-glycosyl-L-asparagine at 103 [ModifiedResidue:9683465] N4-glycosyl-L-asparagine at 322 [ModifiedResidue:9683470] N4-glycosyl-L-asparagine at 432 [ModifiedResidue:9683471] N4-glycosyl-L-asparagine at 546
literatureReference	[LiteratureReference:9683461] ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
name	glycosylated-ACE2 Angiotensin-converting enzyme 2 ACE2_HUMAN
referenceEntity	[ReferenceGeneProduct:217827] UniProt:Q9BYF1 ACE2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9683499] R-HSA-9683480.1
startCoordinate	18
(entityOnOtherCell)	[Reaction:9733495] Viral Spike Binds to ACE2 on Uninfected Cell [Homo sapiens]
(hasComponent)	[Complex:9686311] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] [Homo sapiens] [Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] [Homo sapiens] [Complex:9695376] glycosylated-ACE2:ACE2 inhibitors [plasma membrane] [Homo sapiens] [Complex:9733494] S1 trimer:ACE2:S2 trimer [plasma membrane] [Homo sapiens] [Complex:9770060] Spike trimer:ACE2 [plasma membrane] [Homo sapiens] [Complex:9770062] S1:ACE2 [plasma membrane] [Homo sapiens]
(input)	[Reaction:9678128] Spike glycoprotein of SARS coronavirus binds ACE2 on host cell [Homo sapiens] [Reaction:9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell [Homo sapiens] [Reaction:9695415] glycosylated-ACE2 binds ACE2 inhibitors [Homo sapiens] [Reaction:9733495] Viral Spike Binds to ACE2 on Uninfected Cell [Homo sapiens]
(output)	[BlackBoxEvent:9683488] ACE2 is glycosylated to glycosylated-ACE2 [Homo sapiens] [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Homo sapiens]
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No pathways have been reviewed or authored by glycosylated-ACE2 [plasma membrane] (9683480)