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Details on Person In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins
| Class:Id | LiteratureReference:9683400 |
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| _displayName | In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins |
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| _timestamp | 2020-04-14 21:44:39 |
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| author | [Person:9683394] Athmer, Jeremiah
[Person:9683398] Fehr, Anthony R
[Person:9683397] Grunewald, Matthew
[Person:9680264] Smith, Everett Clinton
[Person:9680281] Denison, Mark R
[Person:9681517] Perlman, Stanley |
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| created | [InstanceEdit:9683395] Orlic-Milacic, Marija, 2020-04-14 |
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| journal | mBio |
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| pubMedIdentifier | 28143984 |
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| title | In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins |
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| volume | 8 |
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| year | 2017 |
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| (literatureReference) | [Summation:9683399] Nonstructural protein 15 (nsp15) of the SARS coronavirus (SA...
[Summation:9694624] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Nonstructural protein 15 (nsp15) of the SARS coronavirus (SARS-CoV-1) binds to the replication-transcription complex (RTC) through interaction with nsp8 (Imbert et al. 2008). This interaction appears to be conserved in other coronaviruses, such as mouse hepatitis virus (MHV) (Athmer et al. 2017). nsp15 is an endonuclease characteristic for the order Nidovirales that includes the family Coronaviridae. nsp15 preferentially cleaves 3' of uridines, generating 2'-3' cyclic phosphates after cleavage. nsp15 requires Mn2+ ions for catalytic activity. Functional nsp15 is needed for production of viable virions and for viral transcription (Guarino et al. 2005, Ricagno et al. 2006, Bhardwaj et al. 2006, Joseph et al. 2007, Bhardwaj et al. 2008, Bhardwaj et al. 2012). The biological role of nsp15 has not been elucidated. It may degrade host mRNAs to shut down host translation, but so far no human or viral RNA targets have been identified.
[Summation:9705958] Nonstructural protein 15 (nsp15) of severe acute respiratory...
[Summation:9754742] Coronaviruses (CoVs) are positive-sense RNA viruses that rep...
[Summation:9755237] Nonstructural protein 15 of severe acute respiratory syndrom... |
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