Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
Class:Id Reaction:9682603 _displayName nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA _doRelease TRUE _timestamp 2020-08-04 17:55:41 authored [InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30 catalystActivity [CatalystActivity:9682604] 3'-5'-RNA exonuclease activity of SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] compartment [Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane created [InstanceEdit:9682611] Orlic-Milacic, Marija, 2020-04-13 disease [Disease:9678120] severe acute respiratory syndrome edited [InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11 input [Complex:9682566] SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:29356] H2O [cytosol] isChimeric FALSE literatureReference [LiteratureReference:9682597] Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing [LiteratureReference:9682560] Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis [LiteratureReference:9682259] One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [LiteratureReference:9682606] Biochemical characterization of exoribonuclease encoded by SARS coronavirus [LiteratureReference:9682548] RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex [LiteratureReference:9683506] Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes modified [InstanceEdit:9683509] Orlic-Milacic, Marija, 2020-04-17 [InstanceEdit:9686424] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686435] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686647] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9689913] D'Eustachio, Peter, 2020-05-22 [InstanceEdit:9690155] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA output [Complex:9682469] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:9689912] NMP [cytosol] precedingEvent
relatedSpecies [Species:9678119] Human SARS coronavirus releaseDate 2020-06-10 reviewed [InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9682612] R-HSA-9682603.3 summation [Summation:9682609] nsp14 acts as 3'-5' exonuclease (Minskaia et al. 2006, Chen ... (hasEvent) [Pathway:9682706] Replication of the SARS-CoV-1 genome [Homo sapiens] (precedingEvent) [BlackBoxEvent:9682465] RTC completes synthesis of the minus strand genomic RNA complement [Homo sapiens]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (9682603)
