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Details on Person Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Class:Id	Reaction:9682572
_displayName	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
_doRelease	TRUE
_timestamp	2022-10-09 06:45:53
authored	[InstanceEdit:9682195] May, Bruce, 2020-04-08
catalystActivity	[CatalystActivity:9682577] guanyl-nucleotide exchange factor activity of Csf1 dimer:p-Y559-Csf1r dimer:Grb2:Sos1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9682571] May, Bruce, 2020-04-11
edited	[InstanceEdit:9682195] May, Bruce, 2020-04-08
input	[Complex:9682581] Kras:GDP [plasma membrane] [Mus musculus] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9682584] Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages [LiteratureReference:9681709] Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors [LiteratureReference:9682764] Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807
modified	[InstanceEdit:9764153] May, Bruce, 2022-02-09 [InstanceEdit:9818020] May, Bruce, 2022-10-08 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
output	[Complex:9682582] Kras:GTP [plasma membrane] [Mus musculus] [SimpleEntity:29420] GDP [cytosol]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9682587] R-MMU-9682572.2
summation	[Summation:9682580] In response to the activation of Csf1r by Csf1, Sos1 bound t...
(inferredFrom)	[Reaction:9680385] CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS [Homo sapiens]
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No pathways have been reviewed or authored by Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras (9682572)