Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person nsp12 misincorporates a nucleotide in nascent RNA minus strand

Class:Id	BlackBoxEvent:9682563
_displayName	nsp12 misincorporates a nucleotide in nascent RNA minus strand
_doRelease	TRUE
_timestamp	2022-04-29 20:05:31
authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9681837] RNA-directed RNA polymerase activity of SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9682565] Orlic-Milacic, Marija, 2020-04-11
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
input	[Complex:9682469] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:6806881] NTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9682597] Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing
modified	[InstanceEdit:9682598] Orlic-Milacic, Marija, 2020-04-13 [InstanceEdit:9682601] Orlic-Milacic, Marija, 2020-04-13 [InstanceEdit:9686424] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686435] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686647] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9687387] Jassal, Bijay, 2020-05-07 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690155] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp12 misincorporates a nucleotide in nascent RNA minus strand
output	[Complex:9682566] SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[BlackBoxEvent:9681674] nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement [Homo sapiens] [BlackBoxEvent:9681651] nsp8 generates RNA primers [Homo sapiens]
regulatedBy	[NegativeRegulation:9687386] Negative regulation by 'SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9682569] R-HSA-9682563.4
summation	[Summation:9682599] In the presence of functional nsp14, which acts as a 3'-to-5...
(hasEvent)	[Pathway:9682706] Replication of the SARS-CoV-1 genome [Homo sapiens]
(inferredFrom)	[BlackBoxEvent:9694792] nsp12 misincorporates a nucleotide in nascent RNA minus strand [Homo sapiens]
(precedingEvent)	[Reaction:9682603] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by nsp12 misincorporates a nucleotide in nascent RNA minus strand (9682563)