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Details on Person UniProt:A3C4S4 GME-1
| Class:Id | ReferenceGeneProduct:9682499 |
|---|---|
| _chainChangeLog | chain:1-378 for 9682499 added on Fri May 15 2020 |
| _displayName | UniProt:A3C4S4 GME-1 |
| _timestamp | 2023-11-03 18:00:08 |
| chain | chain:1-378 |
| checksum | 4BAE83BB932C321A |
| comment | FUNCTION Catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C (L-ascorbate), resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Able to catalyze 2 distinct epimerization reactions and can release both GDP-L-galactose and GDP-L-gulose from GDP-mannose.CATALYTIC ACTIVITY GDP-alpha-D-mannose = GDP-beta-L-guloseCATALYTIC ACTIVITY GDP-beta-L-gulose = GDP-beta-L-galactoseCOFACTOR Strongly activated by NAD. Activated by NADP. Slightly activated by NADH and NADPH. Inhibited by GDP.BIOPHYSICOCHEMICAL PROPERTIES The catalytic efficiency increases by 2-fold in the presence of NAD(+).PATHWAY Cofactor biosynthesis; L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway; L-ascorbate from GDP-alpha-D-mannose: step 1/5.SUBUNIT Homodimer.SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. |
| created | [InstanceEdit:9682524] Gupta, Parul, 2020-04-08 |
| description | recommendedName: GDP-mannose 3,5-epimerase 1 shortName: GDP-Man 3,5-epimerase 1 ecNumber evidence="3"5.1.3.18 alternativeName: OsGME-1 |
| geneName | GME-1 Os10g0417600 LOC_Os10g28200 OsJ_030296 OSJNBa0061K21.15 |
| identifier | A3C4S4 |
| isSequenceChanged | FALSE |
| keyword | Ascorbate biosynthesis Isomerase NAD Reference proteome |
| modified | [InstanceEdit:9682542] Gupta, Parul, 2020-04-08 [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | GME-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GME1_ORYSJ B7EX80 Q0IXP2 Q0R4F5 Q109P5 Q338B5 Q5W7P1 Q8S862 |
| sequenceLength | 378 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:9682506] GDP-D-mannose-3,5-epimerase [cytosol] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:A3C4S4 GME-1 (9682499)
