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Details on Person FLT3 D835N [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9682321
_displayName	FLT3 D835N [plasma membrane]
_timestamp	2020-07-15 14:54:29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9682318] Rothfels, Karen, 2020-04-08
crossReference	[DatabaseIdentifier:9682319] COSMIC:COSV54045151
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9682320] L-aspartic acid 835 replaced with L-asparagine
literatureReference	[LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies [LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
modified	[InstanceEdit:9695708] Rothfels, Karen, 2020-07-15
name	FLT3 D835N STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9682322] R-HSA-9682321.1
startCoordinate	27
(hasComponent)	[Complex:9682344] FLT3 D835N dimer [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9682396] kinase domain mutants of FLT3 [plasma membrane] [Homo sapiens] [DefinedSet:9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699528] sunitinib-resistant FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699534] pexidartinib-resistant FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699535] crenolanib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9703020] ponatinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 D835N [plasma membrane] (9682321)