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Details on Person Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Class:Id	Reaction:9682182
_displayName	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
_doRelease	TRUE
_timestamp	2022-10-09 06:45:23
authored	[InstanceEdit:9681737] May, Bruce, 2020-04-04
catalystActivity	[CatalystActivity:9682169] 1-phosphatidylinositol-3-kinase activity of Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9682186] May, Bruce, 2020-04-08
edited	[InstanceEdit:9681737] May, Bruce, 2020-04-04
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9681113] Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion [LiteratureReference:9680799] Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions [LiteratureReference:9681709] Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors [LiteratureReference:9682749] p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration [LiteratureReference:9682764] Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807 [LiteratureReference:9817985] Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
modified	[InstanceEdit:9682588] May, Bruce, 2020-04-11 [InstanceEdit:9682769] May, Bruce, 2020-04-14 [InstanceEdit:9818020] May, Bruce, 2022-10-08 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9682194] R-MMU-9682182.2
summation	[Summation:9682578] Phosphatidylinositol 3-kinase (PI3K) associated with the act...
(inferredFrom)	[Reaction:9680389] CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 [Homo sapiens]
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