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Details on Person Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Class:Id	Reaction:9682158
_displayName	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
_doRelease	TRUE
_timestamp	2022-10-09 06:45:38
authored	[InstanceEdit:9681737] May, Bruce, 2020-04-04
catalystActivity	[CatalystActivity:9682171] phosphatidylcholine phospholipase C activity of Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9682186] May, Bruce, 2020-04-08
edited	[InstanceEdit:9681737] May, Bruce, 2020-04-04
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:429802] PC [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9680725] Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2 [LiteratureReference:9682181] Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1 [LiteratureReference:9682752] Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling
modified	[InstanceEdit:9682769] May, Bruce, 2020-04-14 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
output	[SimpleEntity:194358] ChoP [cytosol] [SimpleEntity:114519] DAG [plasma membrane]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9682193] R-MMU-9682158.2
summation	[Summation:9682185] In response to Csf1, Plcg2 (phospholipase C gamma2) associat...
(inferredFrom)	[Reaction:9680388] CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine [Homo sapiens]
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No pathways have been reviewed or authored by Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol (9682158)