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Details on Person Virally encoded RNA-dependent RNA polymerase (nsp12, also kn...
| Class:Id | Summation:9681828 |
|---|---|
| _displayName | Virally encoded RNA-dependent RNA polymerase (nsp12, also kn... |
| _timestamp | 2020-05-11 15:38:49 |
| created | [InstanceEdit:9681829] Orlic-Milacic, Marija, 2020-04-06 |
| modified | [InstanceEdit:9681831] Orlic-Milacic, Marija, 2020-04-06 [InstanceEdit:9682267] Orlic-Milacic, Marija, 2020-04-08 [InstanceEdit:9687573] Orlic-Milacic, Marija, 2020-05-11 [InstanceEdit:9687591] Orlic-Milacic, Marija, 2020-05-11 |
| text | Virally encoded RNA-dependent RNA polymerase (nsp12, also known as RdRP) is the key component of the replication transcription complex (RTC). As the human SARS coronavirus 1 (SARS-CoV-1) is a plus strand RNA virus, nsp12 first synthesizes the complementary minus RNA strand. The purified SARS-CoV-1 nsp12 shows both primer dependent and primer-independent RNA synthesis activities using homopolymeric RNA templates. The catalytic activity of nsp12 is strictly dependent on manganese ions (Mn2+) and primers when the template is a viral-genome-derived RNA representing part of the 3’-UTR of the plus strand with a polyA tail. A 36 nucleotide sequence from the 3’-UTR, predicted to form a stable stem-loop structure, seems to be the minimal cis-acting RNA element required for nsp12 to initiate RNA synthesis (Ahn et al. 2012). The complex of nsp7 and nsp8 confers processivity to nsp12 (Subissi et al. 2014). |
| (summation) | [BlackBoxEvent:9681674] nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement [Homo sapiens] |
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No pathways have been reviewed or authored by Virally encoded RNA-dependent RNA polymerase (nsp12, also kn... (9681828)
