Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q63372 Nrxn1
| Class:Id | ReferenceGeneProduct:96818 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Sat February 7 2015;chain:31-1530 added on Sat February 7 2015 |
| _displayName | UniProt:Q63372 Nrxn1 |
| _timestamp | 2026-02-20 23:08:35 |
| chain | signal peptide:1-30 chain:31-1530 |
| checksum | 548109BAF05119FC |
| comment | FUNCTION Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission (By similarity). Function is isoform-specific (By similarity). Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission (By similarity). Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions (By similarity). They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland (By similarity). They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery (By similarity). Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2 (By similarity). In vitro, triggers the de novo formation of presynaptic structures (PubMed:20064387, PubMed:20064388). May be involved in specification of excitatory synapses (PubMed:20064387, PubMed:20064388). Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (PubMed:20064387, PubMed:20064388).SUBUNIT Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer (By similarity). Also interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN2, NLGN3 and NLGN4L; interactions with NLGN1, NLGN2, NLGN3 and NLGN4L are calcium-dependent (PubMed:18093522). Interacts (via cytoplasmic C-terminal region) with CASK (via the PDZ, SH3 and guanylate kinase-like domains) (PubMed:12040031, PubMed:8786425). Interacts (via cytoplasmic C-terminus) with CASKIN1 and APBA1 (PubMed:12040031). Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3 (PubMed:9856994). Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain) (PubMed:11470830). Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 (PubMed:20064387, PubMed:20064388). Interacts with SYT13 and SYTL1 (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Interacts with CLSTN3 (By similarity). Alpha-type isoforms interact with alpha-latrotoxin from spider venom (PubMed:10197529, PubMed:1621094).INTERACTION Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five alternatively spliced sites, each of which may be spliced in up to seven different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 96 isoforms but for simplicity only individual splice events or observed combinations are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4 and 5. Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Brain (neuronal synapse).PTM O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins and LRRTM2.MISCELLANEOUS Alpha-latrotoxin competes with alpha-dystroglycan for binding.SIMILARITY Belongs to the neurexin family. |
| description | recommendedName: Neurexin-1 alternativeName: Neurexin I-alpha alternativeName: Neurexin-1-alpha |
| geneName | Nrxn1 |
| identifier | Q63372 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative promoter usage Alternative splicing Calcium Cell adhesion Cell membrane Cell projection Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Heparan sulfate Membrane Metal-binding Proteoglycan Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Nrxn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NRX1A_RAT |
| sequenceLength | 1530 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:151447] UniProt:Q63373-2 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:151448] UniProt:Q63373-3 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:151449] UniProt:Q63373-4 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240235] UniProt:Q63372-2 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240236] UniProt:Q63372-3 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240237] UniProt:Q63372-4 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240238] UniProt:Q63372-5 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240239] UniProt:Q63372-6 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240240] UniProt:Q63372-7 Nrxn1 [Rattus norvegicus] [ReferenceIsoform:240241] UniProt:Q63372-8 Nrxn1 [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:2426602] Nrxn1 [plasma membrane] [Rattus norvegicus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q63372 Nrxn1 (96818)
