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Details on Person UniProt:P0DTC4 E
| Class:Id | ReferenceGeneProduct:9681692 |
|---|---|
| _chainChangeLog | chain:1-75 for 9681692 added on Fri May 15 2020 |
| _displayName | UniProt:P0DTC4 E |
| _timestamp | 2023-11-03 17:09:44 |
| chain | chain:1-75 |
| checksum | 5C431BD2AA1B6B99 |
| comment | FUNCTION Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by slowing down the cell secretory pathway (PubMed:33229438). May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes (PubMed:32891874).SUBUNIT Homopentamer (PubMed:33177698). Interacts via C-terminus PDM domain with PDZ domain-containing host proteins such as PALS1/MPP5 (PubMed:32891874, PubMed:35283834), TJP1/ZO1 (PubMed:35283834), LNX2 (PubMed:35283834), PARD3 (PubMed:35283834), and AFDN/MLLT4 (PubMed:35283834). This may lead to disruption of tight junctions between epithelial cells (PubMed:32891874). Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein (By similarity).INTERACTION The cytoplasmic tail functions as a Golgi complex-targeting signal.POLYMORPHISM Variant Omicron/BA.1 and BA.2 belong to a lineage first isolated in South Africa (November 2021).POLYMORPHISM Variant Omicron/BQ.1.1 belongs to a lineage first isolated in Nigeria (November 2022).POLYMORPHISM Variant Omicron/XBB.1.5 belongs to a lineage first isolated in United States (November 2022). It is the result of recombination between omicron BJ.1 and BM.1.1. Moreover XBB.1.5 do not express ORF8.SIMILARITY Belongs to the betacoronaviruses E protein family. |
| created | [InstanceEdit:9681685] D'Eustachio, Peter, 2020-04-03 |
| description | recommendedName: fullName evidence="2"Envelope small membrane protein shortName: E shortName evidence="2"sM protein |
| geneName | E 4 |
| identifier | P0DTC4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Apoptosis Host Golgi apparatus Host membrane Membrane Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9681738] D'Eustachio, Peter, 2020-04-04 [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | E |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VEMP_SARS2 |
| sequenceLength | 75 |
| species | [Species:9681683] Severe acute respiratory syndrome coronavirus 2 |
| (referenceEntity) | [EntityWithAccessionedSequence:9694305] 3xPalmC-E [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694310] N-glycan E [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694312] nascent E [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694423] Ub-3xPalmC-E [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694450] N-glycan E [endocytic vesicle membrane] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694465] Ub-3xPalmC-E [endoplasmic reticulum membrane] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694687] Ub-3xPalmC-E [Golgi membrane] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694754] N-glycan E [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9698416] Ub-3xPalmC-E [virion membrane] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9698420] Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2] |
| (referenceSequence) | [ModifiedResidue:9694420] palmitoylated-L-cysteine at 44 [ModifiedResidue:9694532] palmitoylated-L-cysteine at 43 [ModifiedResidue:9694639] N-glycosylated residue at 66 [ModifiedResidue:9694667] ubiquitinylated lysine at 63 [ModifiedResidue:9694742] palmitoylated-L-cysteine at 40 |
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No pathways have been reviewed or authored by UniProt:P0DTC4 E (9681692)
