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Details on Person nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement

Class:Id	BlackBoxEvent:9681674
_displayName	nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
_doRelease	TRUE
_timestamp	2020-08-04 17:55:37
authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9681837] RNA-directed RNA polymerase activity of SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9681677] Orlic-Milacic, Marija, 2020-04-03
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
input	[Complex:9681663] SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:6806881] NTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9681673] Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates [LiteratureReference:9682259] One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
modified	[InstanceEdit:9681830] Orlic-Milacic, Marija, 2020-04-06 [InstanceEdit:9681839] Orlic-Milacic, Marija, 2020-04-06 [InstanceEdit:9681843] Orlic-Milacic, Marija, 2020-04-06 [InstanceEdit:9682267] Orlic-Milacic, Marija, 2020-04-08 [InstanceEdit:9682473] Orlic-Milacic, Marija, 2020-04-08 [InstanceEdit:9682570] Orlic-Milacic, Marija, 2020-04-11 [InstanceEdit:9685528] Orlic-Milacic, Marija, 2020-04-23 [InstanceEdit:9686424] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686435] Orlic-Milacic, Marija, 2020-04-30 [InstanceEdit:9686647] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9687387] Jassal, Bijay, 2020-05-07 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690155] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
output	[Complex:9682469] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[BlackBoxEvent:9681651] nsp8 generates RNA primers [Homo sapiens] [BlackBoxEvent:9682695] nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template [Homo sapiens]
regulatedBy	[NegativeRegulation:9687386] Negative regulation by 'SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9681681] R-HSA-9681674.3
summation	[Summation:9681828] Virally encoded RNA-dependent RNA polymerase (nsp12, also kn...
(hasEvent)	[Pathway:9682706] Replication of the SARS-CoV-1 genome [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand [Homo sapiens]
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