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Details on Person Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity
| Class:Id | LiteratureReference:9681144 |
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| _displayName | Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity |
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| _timestamp | 2020-04-01 13:56:55 |
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| author | [Person:9681150] Xiao, Yibei
[Person:9681146] Ma, Qingjun
[Person:9681149] Restle, Tobias
[Person:9681147] Shang, Weifeng
[Person:4339295] Svergun, Dmitri I
[Person:9681151] Ponnusamy, Rajesh
[Person:9681148] Sczakiel, Georg
[Person:5693769] Hilgenfeld, Rolf |
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| created | [InstanceEdit:9681145] Orlic-Milacic, Marija, 2020-04-01 |
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| journal | J. Virol. |
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| pages | 4444-54 |
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| pubMedIdentifier | 22318142 |
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| title | Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity |
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| volume | 86 |
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| year | 2012 |
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| (literatureReference) | [Summation:9680820] The nsp7:nsp8 heterodimer binds to the RNA-directed RNA poly...
[Summation:9694284] This COVID-19 Reaction instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
The nsp7:nsp8 heterodimer binds to the RNA-directed RNA polymerase (nsp12) of the human SARS coronavirus on the polymerase thumb domain facing the NTP entry channel. Binding in this position sandwiches the RNA polymerase index finger loop between nsp7:nsp8 and the polymerase thumbdomain. The nsp7:nsp8 heterodimer may facilitate the interaction of the viral RNA polymerase with additional components of the RNA synthesis machinery. The second subunit of nsp8 interacts with the viral RNA polymerase interface domain proximal to the finger domain and the RNA template-binding channel, and is not bound to nsp7 (Kirchdoerfer and Ward 2019). This is consistent with the stoichiometry of the complex between feline coronavirus proteins nsp7, nsp8 and nsp12 (Xiao et al. 2012). |
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