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Details on Person The antibiotic azithromycin is used to treat many types of i...
| Class:Id | Summation:9680481 |
|---|---|
| _displayName | The antibiotic azithromycin is used to treat many types of i... |
| _timestamp | 2024-02-20 10:18:22 |
| created | [InstanceEdit:9680494] Jassal, Bijay, 2020-03-27 |
| literatureReference | [LiteratureReference:9680843] From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials |
| modified | [InstanceEdit:9680828] Jassal, Bijay, 2020-03-30 [InstanceEdit:9683526] Jassal, Bijay, 2020-04-17 [InstanceEdit:9685657] Jassal, Bijay, 2020-04-24 [InstanceEdit:9686897] Jassal, Bijay, 2020-05-05 [InstanceEdit:9693550] Jassal, Bijay, 2020-07-02 [InstanceEdit:9773613] Stephan, Ralf, 2022-05-08 [InstanceEdit:9861413] Stephan, Ralf, 2024-02-20 |
| text | The antibiotic azithromycin is used to treat many types of infections affecting the lungs, sinuses and skin. Azithromycin was once the market leader among antibiotics for respiratory tract infections, including Haemophilus influenzae and Moraxella catarrhalis. It interferes with bacterial protein synthesis by binding and inhibiting the 50S ribosomal subunit (Retsema et al. 1997, Jelić & Antolović 2016, Mabe et al. 2004). Azithromycin exerts its antimicrobial activity by blocking the nascent protein exit tunnel. In contrast to other macrolides, two molecules of azithromycin bind simultaneously to the exit tunnel. The additional molecule also interacts with two proteins, L4 and L22, implicated in macrolide resistance (Schlünzen et al. 2003). |
| (summation) | [Reaction:9680493] 50S ribosomal protein binds azithromycin [Homo sapiens] |
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No pathways have been reviewed or authored by The antibiotic azithromycin is used to treat many types of i... (9680481)
