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Details on Person CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine

Class:Id	Reaction:9680388
_displayName	CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine
_doRelease	TRUE
_timestamp	2022-10-09 06:42:33
authored	[InstanceEdit:9680383] May, Bruce, 2020-03-27
catalystActivity	[CatalystActivity:9680387] phosphatidylcholine phospholipase C activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9680384] May, Bruce, 2020-03-27
edited	[InstanceEdit:9680383] May, Bruce, 2020-03-27
inferredFrom	[Reaction:9682158] Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol [Mus musculus]
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:429802] PC [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9682188] The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML [LiteratureReference:9682191] Colony-stimulating factor 1 activates protein kinase C in human monocytes [LiteratureReference:9682160] Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2
modified	[InstanceEdit:9682195] May, Bruce, 2020-04-08 [InstanceEdit:9683195] May, Bruce, 2020-04-14 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine
output	[SimpleEntity:112275] DAGs [plasma membrane] [SimpleEntity:194358] ChoP [cytosol]
precedingEvent	[BlackBoxEvent:9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated [Homo sapiens] [Reaction:389159] CSF1R trans-autophosphorylates on multiple tyrosine and serine residues [Homo sapiens]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9680392] R-HSA-9680388.2
summation	[Summation:9682180] In response to CSF1, PLCG2 (phospholipase C gamma2) associat...
(hasEvent)	[Pathway:9680350] Signaling by CSF1 (M-CSF) in myeloid cells [Homo sapiens]
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No pathways have been reviewed or authored by CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (9680388)