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Details on Person CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS

Class:Id	Reaction:9680385
_displayName	CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
_doRelease	TRUE
_timestamp	2022-10-09 06:42:48
authored	[InstanceEdit:9680383] May, Bruce, 2020-03-27
catalystActivity	[CatalystActivity:9680390] guanyl-nucleotide exchange factor activity of CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9680384] May, Bruce, 2020-03-27
edited	[InstanceEdit:9680383] May, Bruce, 2020-03-27
inferredFrom	[Reaction:9682572] Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras [Mus musculus]
input	[SimpleEntity:29438] GTP [cytosol] [Complex:9680396] S-Farn-Me-PalmS KRAS:GDP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9680395] May, Bruce, 2020-03-27 [InstanceEdit:9680401] May, Bruce, 2020-03-27 [InstanceEdit:9682588] May, Bruce, 2020-04-11 [InstanceEdit:9733353] May, Bruce, 2021-06-03 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
output	[SimpleEntity:29420] GDP [cytosol] [Complex:9680398] S-Farn-Me-PalmS KRAS:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9733330] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 [Homo sapiens] [Reaction:9818010] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 [Homo sapiens]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9680391] R-HSA-9680385.2
summation	[Summation:9682576] SOS1 (SOS) is stably bound to GRB2, which transiently associ...
(hasEvent)	[Pathway:9680350] Signaling by CSF1 (M-CSF) in myeloid cells [Homo sapiens]
(precedingEvent)	[Reaction:9733331] CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 [Homo sapiens]
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No pathways have been reviewed or authored by CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (9680385)