Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated

Class:IdBlackBoxEvent:9680348
_displayNamePIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
_doReleaseTRUE
_timestamp2024-02-07 02:07:47
authored[InstanceEdit:9680351] May, Bruce, 2020-03-14
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9680354] May, Bruce, 2020-03-27
edited[InstanceEdit:9680351] May, Bruce, 2020-03-14
inferredFrom
input[Complex:389153] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] [Homo sapiens]
[DefinedSet:9680346] PIK3CA,B,D:PIK3R1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:984806] PLCG2 [cytosol] [Homo sapiens]
[Complex:912522] GRB2:GAB2 [cytosol] [Homo sapiens]
[Complex:9680372] GRB2:GAB3 [cytosol] [Homo sapiens]
[Complex:182910] CBL:GRB2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:202367] GRAP2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:197940] INPP5D [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:913354] INPPL1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:354251] LYN [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:200917] FYN [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9628701] SRC [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:373640] YES1 [cytosol] [Homo sapiens]
[DefinedSet:1112559] STAT1, STAT3 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9682751] THOC5 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9680750] The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity
[LiteratureReference:9680759] Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes
[LiteratureReference:9680795] Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin
[LiteratureReference:9681718] Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor
[LiteratureReference:9681717] Bryostatin 1 (bryo1)-induced monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinase and M-CSF receptors
[LiteratureReference:9681731] Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells
modified[InstanceEdit:9680383] May, Bruce, 2020-03-27
[InstanceEdit:9680701] May, Bruce, 2020-03-28
[InstanceEdit:9680774] May, Bruce, 2020-03-30
[InstanceEdit:9680996] May, Bruce, 2020-03-31
[InstanceEdit:9681724] May, Bruce, 2020-04-04
[InstanceEdit:9681737] May, Bruce, 2020-04-04
[InstanceEdit:9682769] May, Bruce, 2020-04-14
[InstanceEdit:9733353] May, Bruce, 2021-06-03
[InstanceEdit:9818021] May, Bruce, 2022-10-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9860456] May, Bruce, 2024-02-07
namePIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
output[Complex:9680374] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2022-12-07
reviewed[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9680360] R-HSA-9680348.3
summation[Summation:9680746] The PIK3R1 (p85alpha) subunit of phosphatidylinositol 3-kina...
(hasEvent)[Pathway:9680350] Signaling by CSF1 (M-CSF) in myeloid cells [Homo sapiens]
(precedingEvent)[Reaction:9680388] CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine [Homo sapiens]
[Reaction:9680389] CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (9680348)
Follow Reactome