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Details on Person Ligand-independent dimerization of KIT extracellular domain mutants

Class:Id	Reaction:9680242
_displayName	Ligand-independent dimerization of KIT extracellular domain mutants
_doRelease	TRUE
_timestamp	2020-05-27 10:44:30
authored	[InstanceEdit:9680211] Rothfels, Karen, 2020-03-25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9680243] Rothfels, Karen, 2020-03-26
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9680254] gain_of_function of extracellular domain mutants of KIT [plasma membrane]
input	[CandidateSet:9680195] extracellular domain mutants of KIT [plasma membrane] [Homo sapiens] [CandidateSet:9680195] extracellular domain mutants of KIT [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9679981] Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations [LiteratureReference:9679992] Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate [LiteratureReference:1433334] Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
modified	[InstanceEdit:9680256] Rothfels, Karen, 2020-03-26 [InstanceEdit:9686298] Rothfels, Karen, 2020-04-29 [InstanceEdit:9690167] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of KIT extracellular domain mutants
output	[CandidateSet:9680199] extracellular domain mutant dimers of KIT [plasma membrane] [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9680244] R-HSA-9680242.2
summation	[Summation:9680241] Kit mutations in exon 8 and 9 affect the fifth Ig-like domai...
(hasEvent)	[Pathway:9680187] Signaling by extracellular domain mutants of KIT [Homo sapiens]
(precedingEvent)	[Reaction:9680248] Phosphorylation of extracellular domain KIT mutants [Homo sapiens]
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No pathways have been reviewed or authored by Ligand-independent dimerization of KIT extracellular domain mutants (9680242)