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Details on Person WDR5 recruits MYC to promoters of metabolic genes

Class:Id	Reaction:9680218
_displayName	WDR5 recruits MYC to promoters of metabolic genes
_doRelease	FALSE
_timestamp	2020-03-26 01:40:24
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9680219] Orlic-Milacic, Marija, 2020-03-26
input	[Complex:9680212] (MLL1,MLL2):WDR5 and MYC metabolic target genes [nucleoplasm] [Homo sapiens] [Complex:188378] MYC:MAX [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9679901] Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
modified	[InstanceEdit:9680227] Orlic-Milacic, Marija, 2020-03-26
name	WDR5 recruits MYC to promoters of metabolic genes
output	[Complex:9680217] WDR5:MYC:metabolic target genes [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9679913] WDR5 binds promoters of metabolic genes [Homo sapiens] [Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9680223] R-HSA-9680218.1
summation	[Summation:9680225] Binding to WDR5 facilitates recruitment of MYC to E-box elem...
(hasEvent)	[Pathway:9680220] WDR5 and MYC regulate transcription of metabolic genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9680228] WDR5 and MYC positively regulate transcription of genes needed for biomass increase [Homo sapiens]
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No pathways have been reviewed or authored by WDR5 recruits MYC to promoters of metabolic genes (9680218)