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Details on Person WDR5 binds to promoters of several genes that have MYC-bindi...

Class:IdSummation:9679902
_displayNameWDR5 binds to promoters of several genes that have MYC-bindi...
_timestamp2022-04-18 13:06:52
created[InstanceEdit:9679909] Orlic-Milacic, Marija, 2020-03-25
modified[InstanceEdit:9680215] Orlic-Milacic, Marija, 2020-03-25
[InstanceEdit:9680216] Orlic-Milacic, Marija, 2020-03-26
[InstanceEdit:9770996] Orlic-Milacic, Marija, 2022-04-18
textWDR5 binds to promoters of several genes that have MYC-binding E-box promoter elements. These genes include genes involved in:
mRNA processing: RNPS1
Protein translation: EIF3D and EIF4G3, as well as ribosomal proteins RPL6, RPL7A, RPL7L1, RPL9, RPL11, RPL13, RPL27, RPL29, RPL31, RPL34, RPL35, RPL35A, RPS3, RPS7, RPS10, RPS14, RPS15A, RPS18, and RPS24
Protein folding: CCT7
Cancer-relevant signal transduction: PRRC2B, RGS3, TIAM1
Long non-coding RNAs implicated in cancer: SNHG15, SNHG17, SNORD95. The majority of these genes are thought to be involved in the increase of biomass that is needed for cell division (Thomas et al. 2019).
(summation)[Reaction:9679913] WDR5 binds promoters of metabolic genes [Homo sapiens]
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