Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ITGA4:ITGB1 binds natalizumab

Class:IdReaction:9679740
_displayNameITGA4:ITGB1 binds natalizumab
_doReleaseTRUE
_timestamp2020-05-14 15:35:55
authored[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
definitionInhibition
edited[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
input[ProteinDrug:9679737] natalizumab [extracellular region]
[Complex:198201] ITGA4:ITGB1 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:9685459] Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
modified[InstanceEdit:9679897] Jassal, Bijay, 2020-03-25
[InstanceEdit:9685409] Jassal, Bijay, 2020-04-23
[InstanceEdit:9685462] Jassal, Bijay, 2020-04-23
[InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08
[InstanceEdit:9688550] Jassal, Bijay, 2020-05-14
[InstanceEdit:9688754] Jassal, Bijay, 2020-05-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameITGA4:ITGB1 binds natalizumab
output[Complex:9679842] ITGA4:ITGB1:natalizumab [plasma membrane] [Homo sapiens]
releaseDate2020-06-10
reviewed[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9679873] R-HSA-9679740.2
summation[Summation:9685458] Integrins are the receptors that mediate cell adhesion to th...
(hasEvent)[Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [Homo sapiens]
[Pathway:202733] Cell surface interactions at the vascular wall [Homo sapiens]
[Pathway:216083] Integrin cell surface interactions [Homo sapiens]
[Pathway:9679191] Potential therapeutics for SARS [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by ITGA4:ITGB1 binds natalizumab (9679740)