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Details on Person VEGFA-165 dimer binds VEGFA inhibitors
Class:Id Reaction:9679477
_displayName VEGFA-165 dimer binds VEGFA inhibitors
_doRelease TRUE
_timestamp 2020-06-10 09:30:58
authored [InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
compartment [Compartment:984] extracellular region
created [InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
edited [InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
input [CandidateSet:9679456] VEGFA inhibitors [extracellular region] [Complex:4420158] VEGFA-165 dimer [extracellular region] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:9679491] Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors [LiteratureReference:9679484] Aflibercept in the treatment of patients with metastatic colorectal cancer: latest findings and interpretations [LiteratureReference:9679489] Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study [LiteratureReference:9685108] VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer [LiteratureReference:9685080] Brolucizumab: evidence to date in the treatment of neovascular age-related macular degeneration [LiteratureReference:9679454] Pegaptanib for neovascular age-related macular degeneration [LiteratureReference:9685063] Pegaptanib in the treatment of wet, age-related macular degeneration [LiteratureReference:9685089] Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration [LiteratureReference:9685068] Vascular endothelial growth factor is a critical stimulus for diabetic macular edema [LiteratureReference:9685083] First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors [LiteratureReference:9685091] The McCAVE Trial: Vanucizumab plus mFOLFOX-6 Versus Bevacizumab plus mFOLFOX-6 in Patients with Previously Untreated Metastatic Colorectal Carcinoma (mCRC)
modified [InstanceEdit:9685099] Jassal, Bijay, 2020-04-22 [InstanceEdit:9685409] Jassal, Bijay, 2020-04-23 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9688550] Jassal, Bijay, 2020-05-14 [InstanceEdit:9688754] Jassal, Bijay, 2020-05-14 [InstanceEdit:9691218] Jassal, Bijay, 2020-06-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name VEGFA-165 dimer binds VEGFA inhibitors
output [Complex:9679453] VEGFA-165 dimer:VEGFA inhibitors [extracellular region] [Homo sapiens]
releaseDate 2020-06-10
reviewed [InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9679502] R-HSA-9679477.3
summation [Summation:9685053] In normal development vascular endothelial growth factors (V...
(hasEvent) [Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens] [Pathway:9679191] Potential therapeutics for SARS [Homo sapiens]
(updatedInstance) [_UpdateTracker:9776918] Update Tracker - [Reaction:9679477] VEGFA-165 dimer binds VEGFA inhibitors - v74:[add_removeInput]
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