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Details on Person UniProt:P59636 9b
| Class:Id | ReferenceGeneProduct:9678209 |
|---|---|
| _chainChangeLog | chain:1-98 for 9678209 added on Fri May 15 2020 |
| _displayName | UniProt:P59636 9b |
| _timestamp | 2023-11-03 15:38:34 |
| chain | chain:1-98 |
| checksum | 5166F22872915FCB |
| comment | FUNCTION Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.SUBUNIT Homodimer. Interacts with host XPO1; this interaction mediates protein ORF9b export out of the nucleus (PubMed:21637748). Interacts with host MAVS (PubMed:25135833). Interacts with protein ORF6 (PubMed:22820404).INTERACTION Binds non-covalently to intracellular lipid bilayers.MISCELLANEOUS The gene encoding this protein is included within the N gene (alternative ORF).SIMILARITY Belongs to the coronavirus group 2 protein 9b family. |
| created | [InstanceEdit:9678205] Orlic-Milacic, Marija, 2020-03-13 |
| description | recommendedName: ORF9b protein alternativeName: Accessory protein 9b alternativeName: ORF-9b alternativeName: Protein 9b |
| geneName | 9b |
| identifier | P59636 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Host cytoplasm Host cytoplasmic vesicle Host endoplasmic reticulum Host membrane Host mitochondrion Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host MAVS by virus Inhibition of host RLR pathway by virus Membrane Reference proteome Viral immunoevasion Virion |
| modified | [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | 9b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ORF9B_SARS Q7T6R2 |
| sequenceLength | 98 |
| species | [Species:9678119] Human SARS coronavirus |
| (referenceEntity) | [EntityWithAccessionedSequence:9678210] 9b [plasma membrane] [Human SARS coronavirus] [EntityWithAccessionedSequence:9685182] 9b [mitochondrial outer membrane] [Human SARS coronavirus] [EntityWithAccessionedSequence:9689378] 9b [cytosol] [Human SARS coronavirus] |
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No pathways have been reviewed or authored by UniProt:P59636 9b (9678209)
