Query author contributions in Reactome
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Details on Person Based on findings in a mouse model system, the MLL1 and MLL2...
| Class:Id | Summation:9678075 |
|---|---|
| _displayName | Based on findings in a mouse model system, the MLL1 and MLL2... |
| _timestamp | 2020-03-12 19:35:25 |
| created | [InstanceEdit:9678076] Orlic-Milacic, Marija, 2020-03-12 |
| literatureReference | [LiteratureReference:9678018] Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions [LiteratureReference:9678065] Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex |
| text | Based on findings in a mouse model system, the MLL1 and MLL2 complexes, recruited by PAX7, methylate histone H3 on lysine residue K4, thus creating the activating H3K4me3 mark on nucleosomes at the promoter and enahncers of the MYF5 gene (McKinnell et al. 2008, Kawabe et al. 2012). |
| (summation) | [Reaction:9678077] MLL1,MLL2 methylate H3K4 at MYF5 gene promoter and enhancers [Homo sapiens] |
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No pathways have been reviewed or authored by Based on findings in a mouse model system, the MLL1 and MLL2... (9678075)
