Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person WDR5, as part of an unspecified MLL complex with histone H3K...
| Class:Id | Summation:9677844 |
|---|---|
| _displayName | WDR5, as part of an unspecified MLL complex with histone H3K... |
| _timestamp | 2020-03-11 18:06:49 |
| created | [InstanceEdit:9677847] Orlic-Milacic, Marija, 2020-03-11 |
| literatureReference | [LiteratureReference:9677843] WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1 [LiteratureReference:9677850] Targeting human SET1/MLL family of proteins |
| text | WDR5, as part of an unspecified MLL complex with histone H3K4 trimethyltransferase activity, binds the promoter of the CARM1 gene (Wang et al. 2020), encoding Histone-arginine methyltransferase CARM1. Based on the predominant role of MLL1 and MLL2 complexes in H3K4 trimethylation (Vedadi et al. 2017), it is assumed that WDR5 acts as a component of one of these two complexes at the CARM1 gene promoter. |
| (summation) | [Reaction:9677837] WDR5 binds the promoter of the CARM1 gene [Homo sapiens] |
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No pathways have been reviewed or authored by WDR5, as part of an unspecified MLL complex with histone H3K... (9677844)
