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Details on Person MLL1 trimethylates histone H3 and MYOG gene promoter

Class:Id	Reaction:9677738
_displayName	MLL1 trimethylates histone H3 and MYOG gene promoter
_doRelease	FALSE
_timestamp	2020-03-11 15:11:08
catalystActivity	[CatalystActivity:9677741] histone H3K4 methyltransferase activity of MLL1 complex (p-S49-WDR5) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9677742] Orlic-Milacic, Marija, 2020-03-10
input	[Complex:9677682] MYOG gene:Nucleosome-H3K4me1 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9677086] Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis
modified	[InstanceEdit:9677811] Orlic-Milacic, Marija, 2020-03-11 [InstanceEdit:9677818] Orlic-Milacic, Marija, 2020-03-11
name	MLL1 trimethylates histone H3 and MYOG gene promoter
output	[Complex:9677739] MYOG gene:Nucleosome-H3K4me3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9677206] MLL3 monomethylates H3 at the MYOG gene promoter [Homo sapiens] [Reaction:9677089] PASK phosphorylates WDR5 [Homo sapiens] [Reaction:9677084] mTORC1 phosphorylates PASK [Homo sapiens] [Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [BlackBoxEvent:9818576] Cleaved KMT2A dimers translocate to the nucleus [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9677743] R-HSA-9677738.1
summation	[Summation:9677809] The MLL1 complex which contains WDR5 phosphorylated at serin...
(hasEvent)	[Pathway:9677821] MLLs regulate transcription of myogenesis genes [Homo sapiens]
(precedingEvent)	[Reaction:9677813] MYOD binds MYOG gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by MLL1 trimethylates histone H3 and MYOG gene promoter (9677738)