Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The granulocyte colony-stimulating factor receptor (CSF3R, G...
| Class:Id | Summation:9677582 |
|---|---|
| _displayName | The granulocyte colony-stimulating factor receptor (CSF3R, G... |
| _timestamp | 2020-05-10 06:19:37 |
| created | [InstanceEdit:9677583] May, Bruce, 2020-03-09 |
| modified | [InstanceEdit:9677617] May, Bruce, 2020-03-09 [InstanceEdit:9677623] May, Bruce, 2020-03-09 [InstanceEdit:9677884] May, Bruce, 2020-03-12 [InstanceEdit:9687567] May, Bruce, 2020-05-10 |
| text | The granulocyte colony-stimulating factor receptor (CSF3R, GCSFR, CD114) is a cell-surface receptor for the granulocyte colony-stimulating factor (CSF3, GCSF) (Fukunaga et al. 1990, Larsen et al. 1990). CSF3R is constitutively associated with the kinases LYN (Corey et al. 1994) and JAK1 (Nicholson et al. 1994) and is present on precursor cells in the bone marrow. CSF3 initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. CSF3 exists as a dimer. Only the dimer of CSF3R exhibits high affinity binding to CSF3 (Hiraoka et al. 1994). CSF3R ligand-binding causes dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton and Hall 2006) and signal transduction through JAK-STAT, RAS-RAF-ERK1,2, and PI3K. |
| (summation) | [Reaction:9677579] CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The granulocyte colony-stimulating factor receptor (CSF3R, G... (9677582)
