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Details on Person CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

Class:Id	Reaction:9677579
_displayName	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
_doRelease	TRUE
_timestamp	2020-12-12 08:29:27
authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04 [InstanceEdit:9677580] May, Bruce, 2020-03-07
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9677583] May, Bruce, 2020-03-09
edited	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04 [InstanceEdit:9677580] May, Bruce, 2020-03-07
input	[Complex:8854719] CSF3 dimer [extracellular region] [Homo sapiens] [Complex:9674577] CSF3R:LYN:JAK1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6787732] Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains [LiteratureReference:8854733] Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor [LiteratureReference:8854722] Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme [LiteratureReference:8854727] Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex [LiteratureReference:9674566] Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases [LiteratureReference:9674549] Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation [LiteratureReference:9634363] Three different mRNAs encoding human granulocyte colony-stimulating factor receptor
modified	[InstanceEdit:9677616] May, Bruce, 2020-03-09 [InstanceEdit:9677623] May, Bruce, 2020-03-09 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
output	[Complex:9677584] CSF3 dimer:CSF3R:LYN:JAK1 [plasma membrane] [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9677588] R-HSA-9677579.2
summation	[Summation:9677582] The granulocyte colony-stimulating factor receptor (CSF3R, G...
(hasEvent)	[Pathway:9674555] Signaling by CSF3 (G-CSF) [Homo sapiens]
(precedingEvent)	[Reaction:9677585] CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 [Homo sapiens]
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