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Details on Person PTGS1 dimer binds PTGS1 Inhibitors

Class:Id	Reaction:9677320
_displayName	PTGS1 dimer binds PTGS1 Inhibitors
_doRelease	TRUE
_timestamp	2022-05-10 17:57:22
authored	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05
definition	Inhibition
edited	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[Complex:428986] PTGS1 dimer [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:9677343] PTGS1 Inhibitors [cytosol]
literatureReference	[LiteratureReference:9677655] Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs [LiteratureReference:9677653] Mechanism of action of aspirin-like drugs [LiteratureReference:9677654] Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs [LiteratureReference:9677491] Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
modified	[InstanceEdit:9677519] Jassal, Bijay, 2020-03-05 [InstanceEdit:9677620] Jassal, Bijay, 2020-03-09 [InstanceEdit:9677622] Jassal, Bijay, 2020-03-09 [InstanceEdit:9677657] Jassal, Bijay, 2020-03-10 [InstanceEdit:9758615] Stephan, Ralf, 2021-11-19 [InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTGS1 dimer binds PTGS1 Inhibitors
output	[Complex:9677354] PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9754180] APAP translocates from extracellular region to cytosol [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9677506] R-HSA-9677320.2
summation	[Summation:9677621] Prostaglandins are involved in physiological functions such ...
(hasEvent)	[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
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No pathways have been reviewed or authored by PTGS1 dimer binds PTGS1 Inhibitors (9677320)