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Details on Person PASK phosphorylates WDR5 on serine residue S49. PASK-mediate...

Class:IdSummation:9677191
_displayNamePASK phosphorylates WDR5 on serine residue S49. PASK-mediate...
_timestamp2020-03-10 20:01:03
created[InstanceEdit:9677192] Orlic-Milacic, Marija, 2020-02-28
modified[InstanceEdit:9677194] Orlic-Milacic, Marija, 2020-02-28
[InstanceEdit:9677204] Orlic-Milacic, Marija, 2020-02-28
[InstanceEdit:9677751] Orlic-Milacic, Marija, 2020-03-10
textPASK phosphorylates WDR5 on serine residue S49. PASK-mediated phosphorylation of WDR5 stimulates MLL1-mediated conversion of repressive H3K4me1 mark on the promoter of the MYOG (myogenin) gene to activating H3K4me3 mark, which facilitates MYOD-mediated transcription of the MYOG gene and initiates muscle differentiation. Phosphorylation of WDR5 at S49 does not affect its association with MLL1, MLL2, MLL3, MLL4, SET1 or KAT2A. PASK does not interact with other components of the MLL1 complex except WDR5 (Kikani et al. 2016). Phosphorylation of PASK by the mTORC1 complex is required for PASK-mediated phosphorylation of WDR5 and stimulation of the MYOG gene transcription (Kikani et al. 2019).
(summation)[Reaction:9677089] PASK phosphorylates WDR5 [Homo sapiens]
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