Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:F1M4A4 Kif1a
| Class:Id | ReferenceGeneProduct:9676423 |
|---|---|
| _chainChangeLog | chain:1-1707 for 9676423 added on Sun February 16 2020 |
| _displayName | UniProt:F1M4A4 Kif1a |
| _timestamp | 2025-05-21 22:02:23 |
| chain | chain:1-1707 |
| checksum | 7875216D504B2427 |
| comment | FUNCTION Kinesin motor with a plus-end-directed microtubule motor activity, involved in anterograde axonal transport of synaptic vesicle precursors (By similarity). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons (PubMed:29166604, PubMed:30021165). The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (PubMed:30021165).CATALYTIC ACTIVITY ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate a kinesin associated with a microtubule at position (n+1, toward the plus end).SUBUNIT Dimeric motor; dimerization is required for ATP-driven processive motility (PubMed:19338388). Monomer in vitro (PubMed:19338388). Interacts with PPFIA1 and PPFIA4 (By similarity). Interacts with CALM1; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with PPFIA2 and TANC2; both interactions allow the recruitment of neuronal dense core vesicles to dendritic spines and decrease in presence of calcium (PubMed:30021165). Interacts with SYT4 (unphosphorylated) and SYT11; both interactions increase in presence of calcium (PubMed:29166604, PubMed:30021165). Interacts with MADD (By similarity).INTERACTION Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Expressed in distal regions of neurites.DOMAIN Composed of an N-terminal active core containing the motor domain (MD) and a neck coil (NC), a central regulatory center required for dimerization and activation and containing the FHA domain and coiled coils (CC1 and CC2), and a cargo-recognition region containing a coiled coil (CC3), an undefined region (UDR) and the C-terminal PH domain.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. |
| created | [InstanceEdit:9676415] Weiser, JD |
| description | recommendedName: Kinesin-like protein KIF1A ecNumber evidence="1"5.6.1.3 |
| geneName | Kif1a |
| identifier | F1M4A4 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell projection Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Hydrolase Isomerase Magnesium Membrane Metal-binding Microtubule Motor protein Nucleotide-binding Phosphoprotein Reference proteome Synapse |
| modified | [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | Kif1a |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KIF1A_RAT |
| sequenceLength | 1707 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:F1M4A4 Kif1a (9676423)
