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Details on Person UniProt:P91277-5 hrpk-1
| Class:Id | ReferenceIsoform:9676422 |
|---|---|
| _chainChangeLog | chain:1-397 for 9676422 added on Sun February 16 2020 |
| _displayName | UniProt:P91277-5 hrpk-1 |
| _timestamp | 2023-11-03 15:28:10 |
| chain | chain:1-397 |
| checksum | DC00A065F2753E70 |
| comment | FUNCTION RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development (PubMed:31584932). Promotes the lsy-6-mediated repression of cog-1 in uterine cells (PubMed:31584932). In embryos, may play a role in the DNA damage response (PubMed:15654100).SUBUNIT Interacts with alg-1; the interaction is direct and may be strengthened through RNA-protein association.INTERACTION Localizes to the cytoplasm and nucleus in the germline, oocytes and early embryos (PubMed:31584932). Does not localize to the cytoplasm of somatic cells (PubMed:31584932).ALTERNATIVE PRODUCTS Expressed in gut, muscle, neuronal and hypodermal tissues (PubMed:31584932). Highly expressed in the germline and oocytes (PubMed:31584932).DEVELOPMENTAL STAGE Ubiquitously expressed throughout development (PubMed:31584932). Highly expressed in early embryos (PubMed:31584932).DISRUPTION PHENOTYPE Temperature sensitive with 35% embryonic lethality at 20 degrees Celsius and 80% at 25 degrees Celsius (PubMed:31584932). Of the surviving offspring, 30% are sterile at 20 degrees Celsius and 76% are sterile at 25 degrees Celsius (PubMed:31584932). The majority of non-sterile animals have a reduced brood size (PubMed:31584932). In addition, animals have gonadal formation defects and display a bursting vulva phenotype (PubMed:31584932). Reduced number of miRNAs including miR-58 in embryos and L4 larvae (PubMed:31584932). Defective neuronal cell fate switching, whereby fewer ASEL neurons adopt an ASER cell fate in an lsy-6 mutant background (PubMed:31584932). In young adults, increased number of seam cells and enhanced hypodermal development defects in the double miR-48 and miR-241 mutant (PubMed:31584932). The majority of mutants are embryonic lethal in a miR-35-42 mutant background (PubMed:31584932). Enhanced defects in hypodermal development and alae formation in a let-7 mutant background (PubMed:31584932). RNAi-mediated knockdown relieves the lys-6-mediated repression of cog-1 in uterine cells (PubMed:31584932). RNAi-mediated knockdown results in increased sensitivity to the DNA-damage agent methyl methanesulfonate in embryos, but does not disrupt the morphology of the nucleus (PubMed:15654100). RNAi-mediated knockdown enhances the bursting vulva phenotype in a let-7 mutant background (PubMed:31584932). |
| created | [InstanceEdit:9676415] Weiser, JD |
| description | recommendedName: fullName evidence="7"Heterogeneous nuclear ribonucleoprotein K homolog shortName evidence="5"hnRNP K |
| geneName | hrpk-1 F26B1.2 |
| identifier | P91277 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Nucleus Reference proteome Repeat RNA-binding RNA-mediated gene silencing |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | hrpk-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HRPK1_CAEEL Q8I7G7 Q8I7G8 Q8I7G9 Q8T3B5 |
| sequenceLength | 397 |
| species | [Species:68320] Caenorhabditis elegans |
| variantIdentifier | P91277-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P91277-5 hrpk-1 (9676422)
