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Details on Person UniProt:D3ZIE4 Fyb1
| Class:Id | ReferenceGeneProduct:9676416 |
|---|---|
| _chainChangeLog | chain:1-830 for 9676416 added on Sun February 16 2020 |
| _displayName | UniProt:D3ZIE4 Fyb1 |
| _timestamp | 2023-11-03 17:59:57 |
| chain | chain:1-830 |
| checksum | 4734DA9759534259 |
| comment | FUNCTION Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493).SUBUNIT Part of a complex consisting of SKAP2, FYB1 and PTPNS1 (By similarity). Part of a complex consisting of SKAP2, FYB1 and LILRB3 (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493). Interacts with CLNK (via its SH2 domain) and FYN; this interaction allows SKAP1 and FYB1 to recruit FYN to the complex, thus promoting the phosphorylation of CLNK by FYN (By similarity). Interacts with FYN (By similarity). Interacts with LCP2 (By similarity). Interacts with SKAP1 (PubMed:12681493). Interacts with SKAP2 (By similarity). Interacts with FASLG (By similarity). Interacts with EVL (By similarity). Interacts with TMEM47 (By similarity). Interacts with LCK (By similarity).SUBCELLULAR LOCATION Colocalizes with TMEM47 at cell-cell contacts in podocytes.PTM T-cell receptor ligation leads to increased tyrosine phosphorylation. |
| created | [InstanceEdit:9676415] Weiser, JD |
| description | recommendedName: fullName evidence="1"FYN-binding protein 1 alternativeName: fullName evidence="1"Adhesion and degranulation promoting adaptor protein shortName evidence="1"ADAP alternativeName: fullName evidence="1"FYB-120/130 shortName evidence="1"p120/p130 alternativeName: fullName evidence="1"FYN-T-binding protein alternativeName: fullName evidence="8"SLAP-130 alternativeName: fullName evidence="1"SLP-76-associated phosphoprotein |
| geneName | Fyb1 Fyb |
| identifier | D3ZIE4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell junction Coiled coil Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Reference proteome Repeat SH3 domain |
| modified | [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Fyb1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FYB1_RAT |
| sequenceLength | 830 |
| species | [Species:48895] Rattus norvegicus |
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No pathways have been reviewed or authored by UniProt:D3ZIE4 Fyb1 (9676416)
