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Details on Person Formation of the SET1B complex

Class:IdReaction:9676264
_displayNameFormation of the SET1B complex
_doReleaseTRUE
_timestamp2023-02-13 14:51:01
authored[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9676262] Orlic-Milacic, Marija, 2020-02-11
edited[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
input[Complex:9675213] WRAD complex [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5244714] SETD1B [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9676266] The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases
[LiteratureReference:9772102] Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes
[LiteratureReference:9772762] Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
[LiteratureReference:9772918] Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex
modified[InstanceEdit:9676833] Orlic-Milacic, Marija, 2020-02-21
[InstanceEdit:9771339] Orlic-Milacic, Marija, 2022-04-19
[InstanceEdit:9771347] Orlic-Milacic, Marija, 2022-04-19
[InstanceEdit:9771883] Orlic-Milacic, Marija, 2022-04-20
[InstanceEdit:9772104] Orlic-Milacic, Marija, 2022-04-20
[InstanceEdit:9772489] Orlic-Milacic, Marija, 2022-04-22
[InstanceEdit:9772571] Orlic-Milacic, Marija, 2022-04-22
[InstanceEdit:9772772] Orlic-Milacic, Marija, 2022-04-23
[InstanceEdit:9772926] Orlic-Milacic, Marija, 2022-04-24
[InstanceEdit:9818583] Orlic-Milacic, Marija, 2022-10-19
[InstanceEdit:9821915] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9821916] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9821917] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9821918] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9828146] Orlic-Milacic, Marija, 2023-02-10
[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
[InstanceEdit:9828331] Orlic-Milacic, Marija, 2023-02-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFormation of the SET1B complex
output[Complex:9676269] SET1B complex [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2023-03-29
reviewed[InstanceEdit:9827909] Van, Hieu, 2023-02-08
[InstanceEdit:9827910] Ge, Kai, 2023-02-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9676278] R-HSA-9676264.2
summation[Summation:9676270] SETD1B (also known as SET1B) binds the WRAD complex, consist...
(hasEvent)[Pathway:9772755] Formation of WDR5-containing histone-modifying complexes [Homo sapiens]
(precedingEvent)[Reaction:5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) [Homo sapiens]
[Reaction:5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) [Homo sapiens]
[Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) [Homo sapiens]
[Reaction:9818244] SET1B complex binds target gene loci [Homo sapiens]
[Reaction:9821476] CXXC1 and WDR82 bind SET1B complex [Homo sapiens]
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